643 Grand Avenue, SOUTH SAN FRANCISCO, CA 94080 (MLS # ML82059314)

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PRICE $1,248,000
BEDS 3
BATHS 4
HOME SIZE 1,630 sqft
LOT SIZE 3,500.00 ac
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Ideally located near Downtown South San Francisco and the cities thriving biotech and life-sciences corridor, 643 Grand Avenue where space, comfort, and a remarkable garden setting come together in the heart of South San Francisco. 643 Grand Avenue offers a spacious and versatile layout with excellent access to major transportation and employment centers. The home features 3 bedrooms and 4 bathrooms, with a private full bathroom for each bedroom. Additional highlights include high ceilings, abundant natural light, hardwood floors, a full basement with ample storage, and a detached 2-car garage equipped with a 220-volt outlet for EV charging. The home also features a water purification system, tankless water heater, and water softener. The quaint lot includes a freshly manicured organic vegetable garden with sunflowers and offers potential for an ADU. Conveniently located near Downtown South San Francisco, Genentech, Caltrain, US-101, and I-280.

LAST UPDATED 8/27/2026 YEAR BUILT 1895
GARAGE SPACES 2.0 COUNTY San Mateo
STATUS Active PROPERTY TYPE(S) Single Family


ADDITIONAL DETAILS
AIR None
APPLIANCES Water Softener
GARAGE Yes
HEAT Central, Forced Air
INTERIOR Walk-In Closet(s)
LOT 3500 acre(s)
LOT DIMENSIONS 3500.00
PARKING On Street, Detached
POOL DESCRIPTION None
SEWER Public Sewer
STORIES 2
WATER Public
ZONING RM0000
Listed by Jill Penna | 415-244-8630, Christie's International Real Estate Sereno

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Based on information from MLSListings MLS as of 8/29/26 1:36 PM PDT. All data, including all measurements and calculations of area, is obtained from various sources and has not been, and will not be, verified by broker or MLS. All information should be independently reviewed and verified for accuracy. Properties may or may not be listed by the office/agent presenting the information.

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